Blacktongue and Nicotinic Acid Metabolism: Philip Handler
نویسندگان
چکیده
منابع مشابه
Nicotinic Acid Metabolism
Previous reports from this laboratory have described the isolation of 6-hydroxynicotinic acid and 6-0x0-1 ,4,5,6-tetrahydronicotinic acid from the reaction media of a clostridial species grown on nicotinic acid (1). Bn enzyme that catalyzes the reversible oxidation of nicotinic acid to HNA’ has been purified from extracts of this microorganism (2). Since fortified crude extract of this Clostrid...
متن کاملNicotinic acid metabolism. 3. Purification and properties of a nicotinic acid hydroxylase.
An enzyme that catalyzes the reversible hpdroxylation of nicotinic acid to 6-hydroxynicotinic acid has been purified from extracts of a nicotinic acid-fermenting clostridium. The enzyme appears to be a flavin adenine dinucleotidecontaining non-heme iron protein and utilizes triphosphopyridine nucleotide as the ultimate electron acceptor. The purified enzyme also exhibits reduced triphosphopyrid...
متن کاملNicotinic acid metabolism. II. The isolation and characterization of intermediates in the fermentation of nicotinic acid.
6-Hydroxynicotinic acid was demonstrated to be the first intermediate in the degradation of nicotinic acid by a clostridium. In the presence of pyruvate, other intermediates accumulated; two of these were identified, one as 1,4,5,6tetrahydro-6-oxonicotinic acid, and the other as a!-methyleneglutaric acid. The pathways for nicotinic acid degradation may be considered as involving successive oxid...
متن کاملN-Formylmaleamic acid: an intermediate in nicotinic acid metabolism.
Jiménez et al. (1) have published a thorough and impressive analysis of the genetic determinants of aerobic nicotinic acid degradation in Pseudomonas putida. The chemistry of this pathway has been known for some time (2) with the exception of the formation and hydrolysis of the (up to now) putative intermediate, N-formylmaleamic acid. These gaps were due to (i) difficulties in the synthesis of ...
متن کاملMetabolism of nicotinamide and nicotinic acid in Neurospora crassa.
Nicotinic acid is outstanding among the B vitamins in that its metabolic fate has been very extensively investigated. These studies, however, have been carried out mostly in higher animals, and they have revealed that (i) N'-methylnicotinamide is, in general, the major end-product of the metabolism of both nicotinic acid and nicotinamide; (ii) nicotinuric acid, the glycine conjugate of nicotini...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)67862-0